CV Lattes
Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Biomedicina from Universidade de Santo Amaro (2010). , acting on the following subjects: crotoxin and scfv. (Source: Lattes Curriculum)
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Our goal in this project is to study the affinity of mutant human antibody scFv anti-crotoxin, seeking to understand the mechanisms of action of crotoxin and a possible alternative treatment for poisoning by the bite of snakes of the genus Crotalus. Crotalus poisoning, although accounting for only 8% of cases, it has the highest mortality. The venom has several toxins, crotoxin (CTX) prim…
Administration of heterologous antibodies, generally produced in horses, has been the treatment of choice to persons who suffered accidents by snake venoms. However, this kind of therapy can induce adverse reactions. Small fragments of antibodies containing only the VH and VL domains, known as Fv (Fragment variable) or single chain Fv (scFv) were constructed by genetic engineer aiming to …
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