CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Professor Dr. Guilherme, affiliated with the Department of Biochemistry and Tissue Biology at the Institute of Biology, University of Campinas (UNICAMP), holds a solid background in Biological Sciences and a Ph.D. in Cellular and Structural Biology, both from UNICAMP. His expertise encompasses molecular biology, cell biology, extracellular matrix, and cellular signaling, with a focus on areas such as extracellular matrix, morphogenesis, and cell signaling. Prof. Guilherme is skilled in advanced techniques, including RNA interference, CRISPR/Cas9, cell culture, optical microscopy, and image analysis.During his postdoctoral research at the University of California, San Francisco, he specialized in the role of heparan sulfate and extracellular matrix components in ctoneme-mediated signaling, using the model organism Drosophila melanogaster. His research involved advanced molecular biology, in vivo imaging, and confocal microscopy. In addition to his dedication to scientific research, Prof. Guilherme is actively involved in training new scientists and contributes to scientific and technological development in the field of biological sciences. (Source: Lattes Curriculum)
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Most paracrine signaling morphogens are heparan sulfate (HS) ligands. This property of HS is extremely significant for cellular signaling activity during the development and homeostasis of organs and tissues. It is known that the interaction between HS ligands and HS is primarily ionic. Therefore, characterizing this interaction at the molecular level is important for deepening the unders…
Ventral prostate morphogenesis occurs during the first three weeks of rats and involvis cavitation of the epithelial cords due to the polarization and differentiation of the epithelial cells in contact to the basal membrane that survives and the internal cells apoptosis. There is a signaling made by many extracellular factors between stroma and epithelia that controls these events. Among …
Prostate morphogenesis, as in other branched organs, such as kidney, salivary gland and lung, depends on well regulated epithelial-stromal interactions. The two compartments exchange molecular clues either by ECM remodeling, cell contact or soluble signaling molecules. Some of these molecules, such as growth factors, bind to heparan sulfate proteoglycans (HSPGs), which dictate the dynamic…
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