Lucas Eduardo Botelho de Souza

Coordinator of the Gene Transfer Laboratory of the Ribeirão Preto Blood Center (FMRP/USP). He holds a Bachelor's degree (2010) in Biological Sciences from the School of Philosophy, Sciences and Letters of Ribeirão Preto (USP). He holds a Master's degree in Biomedical Research (2012) and a PhD in Stem Cells and Cell Therapy (2016) from the School of Medicine of Ribeirão Preto (USP). He completed his postdoctoral studies at thematic unit 935 of INSERM (France), focusing on the biology of leukemic stem cells (2019). He is currently developing basic and applied studies in advanced cell therapy, focusing on the development of genetically modified T cells for the treatment of neoplasms. He has regulatory experience in the area of #8203;#8203;advanced therapies, as he was the director of preclinical studies that supported the approval of the clinical trial (CARTHEDRALL-01), which aims to investigate anti-CD19 CAR-T cells in the treatment of leukemia and lymphoma. He also coordinates the development of analytical methods for quality control for CAR-T cells based on digital PCR. Currently, research efforts are directed at understanding the intrinsic and extrinsic mechanisms that regulate the antitumor activity of genetically modified T cells and developing methods that facilitate access and increase the efficacy of these therapies. He is a master's and doctoral advisor in the postgraduate program in Clinical Oncology, Stem Cells and Cell Therapy at the Ribeirão Preto School of Medicine (USP). (Source: Lattes Curriculum)