Abstract
Flagellin is an agonist of TLR and NLR receptors that has been extensively investigated as an adjuvant. Innate immune recognition of flagellin is shared by transmembranic TLR5 and cytosolic Naip5/NLRC4 inflammasome complex. We have demonstrated a process of necrotic cell death induced by cytosolic flagellin that does not require NLRC4, ASC or caspase-1/11 but it is regulated by lysosomal …