Abstract
Tuberous sclerosis complex (TSC) is a hamartomatosis due to mutations in either tumor suppressor gene, TSC1 or TSC2, which codes for hamartin and tuberin, respectively. These proteins form a macromolecular, cytosolic complex that regulates cell proliferation, differentiation, growth and migration, aspects commonly deficient in TSC hamartoma cells. Although TSC hamartomas may affect any or…