CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences from the University of Santo Amaro (1982), improvement in Experimental Pathophysiology from the Butantan Institute (FUNDAP - 1986), Masters (1993), and Doctorate (1999) in Experimental and Comparative Pathology from the Faculty of Veterinary Medicine and Animal Science of the University from Sao Paulo. Currently is a senior Scientific Researcher and head of the Laboratory of Pathophysiology at the Butantan Institute, Vice Coordinator of the Graduate Program in Science (area: Toxinology), and coordinator of the especialization course on Toxins of Interest in Health, at the Butantan Institute. Also, coordinates the Ethical Comitee in Animal Use of Butantan Institute. He has experience in Pathophysiology, emphasizing Animal Toxins, working on the following topics: animal venoms, Bothrops jararaca, Crotalus durissus terrificus, Lonomia obliqua, local lesions, antivenom therapy, inflammation, edema, microcirculation. (Source: Lattes Curriculum)
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In Brazil, an average of 29,000 snakebites occurs each year. Of these, accidents caused by snakes of the genus Bothrops are the most frequent (86% of the total) and are the ones that cause the more severe local reactions. Signs as massive edema, local and systemic hemorrhages, and necrosis in skin and muscles are frequent in these envenoming and often result in debilitating sequelae. The …
The Bothrops jararaca snake plasma is rich in protease inhibitors, some of which have inhibitory activity on toxins from its own venom. One of these, which have a molecular mass of 110 kDa, is a potent inhibitor of cysteine proteases and releases a peptide that induces contraction of homologous smooth musculature. For these characteristics this protein, named BjHK (Bothrops jararaca High …
The venom of Bothrops jararaca causes exuberant inflammatory reactions in mammals, but these snakes are resistant to their own poison in their plasma and have a large amount of protease inhibitors. One of these inhibitors, the BjHK (Bothrops jararaca high molecular weight kininogen) inhibits metalloproteinases of the venom of B. jararaca, primarily responsible for the inflammatory respons…
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