Abstract
Local anesthetics (LA) are amphiphile molecules that reversibly bind to the sodium channel of excitable membranes, curbing nervous impulse propagation. An ideal LA molecule should have long duration and low toxicity. This project aims to prepare and to characterize a new drug-delivery system with polylactide-glycolide nanoparticles (50:50 PLGA) for dibucaine designed to enhance its pharma…