Abstract
The application of cardiopulmonary bypass (CPB) in cardiovascular surgery began in the 1950s. Since then, much has been studied about the Systemic Inflammatory Reaction Syndrome (SIRS) associated with CPB. It is known that CPB-associated SIRS has a multifactorial cause, with pro-inflammatory cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-±)…