Abstract
Proteoglycans (PGs) are macromolecules widely distributed in animal tissues. They are important components of extracellular matrix and cell surface. PG degradation occurs mainly in lysosomes after endocytosis, by the action of proteases and endoglycosidases. These enzymes act upon the protein core and the glycosaminoglycan (GAG) side chains, respectively. Smaller fragments of GAGs are deg…