Abstract
Diuron (3-(3,4- Dichloropenyl)- 1,1- dimethylurea) is an urea-derived herbicide used in several crops types that induces urothelial tumors in Wistar rats fed 2500ppm during 2 years. The suggested non-genotoxic carcinogenic mode of action involves: metabolic activation mainly N- (3,4- dichlorophenyl) urea (DCPU) and 4,5-dichloro-2-hydroxyphenyl) urea (2-OHDCPU), cytotoxicity, necrosis, exf…