CV Lattes
ResearcherID
ORCID
Google Scholar Citations
Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Medicina from Faculdade de Medicina de Ribeirão Preto - USP (1984), master's at Neurologia from Escola Paulista de Medicina - UNIFESP (1990) and ph.d. at Neurology from Universidade Federal de São Paulo (1992). Has experience in Medicine, focusing on Neurology, acting on the following subjects: epilepsia do lobo temporal, temporal lobe epilepsy, epilepsy surgery, esclerose hipocampal and hippocampal sclerosis. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Nearly half of the patients with epilepsy have poor seizure control, even after more than a century of advances in pharmacological treatment. For some of these drug-resistant cases, surgery may be the indicated treatment. In these cases, surgical success is directly linked to the correct location of the epileptogenic zone (EZ; i.e., the brain area responsible for seizure generation), and …
Nearly half of the patients with Epilepsy have poor seizure control, even after more than a century of advances in pharmacological treatment. For some of these drug-resistant cases, surgery may be the indicated treatment. In these cases, surgical success is directly linked to the correct location of the epileptogenic zone (EZ; i.e., the brain area responsible for seizure generation), and …
Respiratory disorders and cerebrovascular diseases are highly prevalent worldwide, and there are mounting clinical and epidemiological evidence of a strong causal relation between them. A better comprehension of such interaction could result in advances in treatment and prevention of both conditions, with considerable public health impact.Stroke is the second leading cause of death and th…
The project is devoted to the characterization of the anatomophysiological, neurochemical and electrophysiology bases of epilepsies. The main objective of this group is the development of animal models of epilepsy to improve our knowledge about the possible synaptical and nonsynaptical mechanisms responsible for epileptogenesis and antiepileptogenesis processes. Among them, the neural sub…
(Only some records are available in English at this moment)
Depression is the most prevalent psychiatric comorbidity in Temporal Lobe Epilepsy (TLE). Clinical and experimental works point to dysfunctional activity in neural circuits shared by both pathologies. In this sense, discriminating these circuits involved in ELT associated with depression is still a challenge, but investigated circuits associated with depressive-like behaviors per se could…
Rats submitted to Status epilepticus (SE) during development present behavioral changes typical of animal models of psychosis, which correlate with changes in synaptic plasticity between the hippocampus and the prefrontal cortex (CPF). Our hypothesis is that SE affects the connectivity of meso-cortico-limbic circuits, which may underlie psychiatric comorbidities observed in epilepsy. Our …
The perception of control over stress is one of the main determinants of the degree of its influence on the organism. Animal models of neuropsychiatric disorders, especially depression, are usually based on uncontrollable stressors and the consequent generalization of the expectancy of uncontrollability over future stimuli, a phenomenon consistent with the clinical condition. Nevertheless…
The homeostatic synaptic plasticity keeps the patterns of neuronal activity within a physiological range, acting through negative feedback in situations of neuronal hypoactivity or hyperactivity. This kind of plasticity controls the postsynaptic response through of receptors expression and dendritic spines density (synaptic scaling), besides modulates the inhibitory control mediated by in…
(Only some records are available in English at this moment)
Magnetic resonance imaging (MRI) is an important non-invasive tool for the evaluation of several conditions. In drug-resistant epilepsies, surgical outcome depends largely on complete removal of the epileptogenic region, making MRI crucial for surgical planning. Cortical dysplasias, one of the most common pathological findings in young drug-resistant patients, can remain undetected by MRI…
How do memories persist? Network activity during sleep is thought to support memory through a process known as systems consolidation. In this process, neuronal circuits are reorganized, and new cell assemblies are bound with neurons that were previously activated during acquisition of the memory itself. In particular, reorganization between the hippocampus and the medial prefrontal cortex…
The medial prefrontal cortex (MPFC) is implicated in top-down control of action timing. MPFC single unit activity was shown to follow two patterns during timing tasks: a sustained delay-related activity inhibiting motor commands, and a ramping activity that could represent the passage of time. Dopaminergic projections from the ventral tegmental area (VTA) to the MPFC have been implicated …
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 26 / 12 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 48 / 18 | Completed scholarships in Brazil |
| 6 / 5 | Completed scholarships abroad |
| 84 / 39 | All research grants and scholarships |
| Associated processes | |