Claudia Cristina Biguetti

• Abstract

  Bone formation and bone resorption can be influenced by different inflammatory factors, such as the products from Arachidonic Acid (AA) metabolism. In this context, the AA products metabolized by 5-lipoxigenase (5-LO), such as the leukotrienes LTB4 and CysLT, have a resorptive effect, since they stimulate the increase of osteoclastogenesis. This study aim to analyze the role of 5-lipoxyge…

  Role of 5-lipoxygenase enzyme (5-LO) on the intramembranous and endochondral bone phenotype: comparative macroscopic and microscopic anatomy between 129/Sv-WT and 129/Sv 5-LOKO mice, BP.IC

• Abstract

  Interactions between bone and muscular tissue as parts of the musculoskeletal system are beyond their structural and mechanical functions, including stimulation of inflammatory contexts. It has been demonstrated that both muscle and bone may act mutually regulating immune system, as the case in the development of chronic diseases related to ageing (osteoporosis and sarcopenia), and also a…

  The role of 5-Lypoxigenase (5-LO) on the musculoskeletal system: a comparative analysis of regenerative and senescence processes in 129/Sv-WT vs. 129/Sv 5-LOKO, BP.PD

• Abstract

  Biomaterial implantation leads to an inflammatory response that may play a crucial role in the clinical success or failure outcome. In this process, monocytes/macrophages are supposed to play a central role, since these cells are considered the main body sensors related to biocompatibility. However, this interaction between host/biomaterial is poorly understood at the cellular and molecul…

  Role of DAMPs in the modulation of macrophage response after classical biomaterial (Ti) implantation and its impact in the subsequent repair and osseointegration processes, BP.DR

(Only some records are available in English at this moment)

• Abstract

  The integration and maintenance of permanent biomaterials, such as titanium (Ti)-based devices, depends on its ability to not elicit a damaging immune response and its capacity to trigger and support an appropriate healing process. However, the molecular and cellular basis of immediate and long-term host/biomaterial interaction is poorly understood, even in classical biomaterials such as …

  Influence of biomaterial (Ti) experimental biological aging in the outcome of host response to biomaterial grafting in vivo and stem cells (SCAPs) differentiation in vitro, BE.EP.DR