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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Ciências Farmacêuticas (FCFAR) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Thiago Aparecido da Silva in research grants and scholarships supported by FAPESP.
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The Ministry of Health adopted the measurement of the release of Interferon-gamma (Interferon gamma release assay-IGRA) as a clinical test for the detection of Latent Tuberculosis (TB) caused by Mycobacterium tuberculosis. The IGRA test is necessary for public policy aimed at people living with HIV (T-CD4+ lymphocyte count > 350 cells/mm³), children who are contacts of active TB cases (2 …
Invasive fungal infections (IFIs) show mortality at similar and higher levels compared to tuberculosis and malaria. Regarding neglected diseases, IFIs have a low financial support while tuberculosis and malaria are better supported. Since IFIs, candidiasis, aspergilosis, criptococosis and histoplasmosis have more effect on the global public health. The risk factors of IFIs are related to …
Chimeric Antigen Receptor (CAR) therapy is a new approach that utilizes bioengineering to modify immune cells so they are able to specifically target and kill pathogens or altered host immune cells (such as cancers). This approach involves generating modified cell surface molecules (chimeric receptors) and expressing these receptors in host immune cells. As these chimeric receptors recogn…
(Only some records are available in English at this moment)
Chimeric Antigen Receptor (CAR) therapy is a new approach that utilizes bioengineering to modify immune cells so they are able to specifically target and kill pathogens or altered host immune cells (such as cancers). This approach involves generating modified cell surface molecules (chimeric receptors) and expressing these receptors in host immune cells. As these chimeric receptors recogn…
Invasive candidiasis is a severe fungal infection caused by species of the Candida genus, such as Candida albicans, Candida glabrata, Candida tropicalis, and Candida auris. It is more prevalent in immunocompromised patients and associated with high mortality rates. Treatment with antifungals, such as azoles, polyenes, and echinocandins, can lead to severe adverse effects and face resistan…
B-cell neoplasms represent a significant portion of hematologic malignancies and are associated with therapeutic challenges due to the toxicity of conventional treatments and recurrence. CAR-T cell therapy is characterized by the use of chimeric antigen receptors (CAR) with the ability to redirect the cytotoxic activity of modified T cells in a target-specific manner, as demonstrated by t…
Human cryptococcosis, an infection caused by Cryptoccocus spp., was classified by the WHO as a high priority for the development of therapies. Cryptococcosis has an estimated global annual incidence of 1 million cases, being an invasive fungal infection (IFI) with the lowest percentages of investment in research among neglected diseases. The genomic plasticity of Cryptococcus spp. associa…
(Only some records are available in English at this moment)
Paracoccidioidomycosis (PMC), caused mainly by the fungus Paracoccidioides brasiliensis, is a systemic granulomatous mycosis of higher prevalence in South America with high correlation with individuals having rural activities. PMC caused about 51% of deaths caused by systemic mycoses in Brazil between the years 1996 and 2006, according to data from the Ministry of Health. The infection oc…
Paracoccidioides brasiliensis is a pathogenic fungus belonging to the genus Paracoccidioides that has a restricted location a Latin America with the highest occurrence of cases in Brazil, Colombia and Venezuela. It is dimorphic and presents the carbohydrate ±-1,3-glucan, a virulence factor that compromises the recognition of the fungus by cells of innate immunity through pattern recogniti…
Invasive Candidiasis is an infection caused mainly by Candida albicans and is often associated with high rates of mortality. Candida infections affect 80% of the patients among all fungal infections in hospitals and, in Brazil, the incidence of Candidemia is approximately 2.5 cases in 1000 hospital admissions. Controlling Invasive Fungal Infections (IFIs) depends strongly on the innate im…
(Only some records are available in English at this moment)
T cell interaction with antigen presenting cell (APC), in which T-cell receptor (TCR) recognizes peptide-MHC complexes (p-MHC), is required to recruit downstream signaling molecules and trigger T cell activation. It was recently demonstrated that chimeric antigen receptor (CAR) expressed on T cells recognizes proteins, glycoproteins, and glycolipids as potential targets on cells surface, …
| 4 / 4 | Ongoing grants |
| 3 / 1 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 18 / 18 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 32 / 30 | All research grants and scholarships |
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