Abstract
Zidovudine, azidothymidine (AZT) is the drug most used alone or in combination with other antiretroviral agents for the treatment of AIDS (Acquired Immunodeficiency Syndrome), caused by HIV (human immunodeficiency virus). The low bioavailability of AZT is the major challenge to be overcome to optimize their performance on oral therapy, since its high rate of hepatic metabolism and low per…