Abstract
Glioblastomas multiform (GBMs) are more invasive tumors of the central nervous system, their invasiveness is related to the interaction with extracellular matrix glycoproteins such as fibronectin and vitronectin. These integrins interact with glycoproteins present in tumor cells facilitating adhesion and migration of these cells into brain tissue. Integrins, ±5²1, ±v²5, and ±v²3 are stron…