Abstract
High mobility group box 1 (HMGB1) is a highly conserved protein present in the nuclei and cytoplasm of nearly all cell types. Recent investigations have indicated that HMGB1 has proinflammatory cytokine activities when released in the extracellular milieu. Thus, it has been suggested that HMGB1 is involved in the process of several acute and chronic inflammatory diseases. This secretion o…