Abstract
Using the resources of the Technical Reserve for Institutional Infrastructure according to the rules specified by FAPESP. (AU)
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Paolo Di Mascio
CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Tecnologia Biomédica from Université Catholique de Louvain (1987), bachelor's at Química Clínica from Université Libre de Bruxelles (Couvreur- De Mot) (1984) and doctorate at Tecnologia Biomédica from Universidade de Düsseldorf /Université Catholique de Louvain (1989). Has experience in Biochemistry, focusing on Metabolism and Bioenergetics, acting on the following subjects: singlet oxygen, dna, dna, dna damage and mass spectrometry. (Source: Lattes Curriculum)
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Research grants
- Implementation Plan of the Technical Reserve for Institutional Infrastructure Financial Resources granted in 2019., AP.RT.INST
- Implementation Plan of the Technical Reserve for Institutional Infrastructure Financial Resources granted in 2016, AP.RT.INST
Abstract
Using the resources of the Technical Reserve for Institutional Infrastructure according to the rules specified by FAPESP. (AU)
- Multi-user equipment approved in grant 2014/25980-0: diferencial scanning calorimeter, DSC, AP.EMU
Abstract
Substitution al the Analytical Chemistry Instrumentation Facility at (IQ-USP) of a Differential Scanning Calorimeter equipment, DSC. This is currently critical to the continued development of competitive research at the frontier of knowledge. The technique is extremely important for research in chemistry and biochemistry about structure and structural changes of molecules with application…
(Only some records are available in English at this moment)
Scholarships in Brazil
- Study of oxidation of thiols and disulfide bonds by singlet oxygen and redox proteomics of keratinocytes exposed to light, BP.DD
Abstract
Singlet molecular oxygen (1O2) is a reactive oxygen species that, once present in cells, has the ability to oxidize biomolecules such as proteins, lipids and DNA. Previous results have shown that the reaction of 1O2 with thiols and disulfide bonds generates oxidation products in peptides and proteins. In light of this, the following research project seeks to study the mechanisms of oxidat…
- Singlet molecular oxygen produced by UVA irradiation after incorporation of 6-Thioguanine into DNA, BP.DD
Abstract
Singlet molecular oxygen (1O2) has been shown to be generated in biological systems. Biological targets for 1O2 include unsaturated fatty acids, proteins, and DNA. Preliminary results obtained in an undergraduate research project showed that 0.2 to 4 % of 6-thioguanine (6-TG) is incorporated in the DNA of HaCat epithelial cells. In this view, this research project aims to use 6-thioguanin…
- Comet Assay: Detection of Damage Induced by UVA Light After Incorporation of 6-Thioguanine into the DNA of Human Keratinocytes, BP.IC
Abstract
Even though the solar light is crucial to life, playing major roles in human physiology, it is also one of the most important and ubiquitous carcinogens to which humans are exposed. The ultraviolet (UV) component emitted by the sun is composed of UVC, UVB and UVA. However, UVC is completely absorbed by the atmosphere, making UVA and UVB wavelengths of major relevance for human health. UV …
- Mechanistic Study of the Oxidation of Dehydroalanines by Singlet Oxygen, BP.IC
Abstract
Dehydroalanines are present in organisms and are generally found in toxic peptides, antibiotics or modified proteins. The existence and permanence of these species in humans has become a curious fact, since these aminoacids are not used in the synthesis of proteins and their olefin structure is a potential target for oxidants. Therefore, this study aims to study the reactivity of dehydroa…
- Multifunctional fluorescence quantum dots as amplifiers for 1O2 generation and synergistic enhanced photodynamic therapy, BP.PD
Abstract
The development of multifunctional nanoplatform with integrated diagnostics and simultaneous local therapy, while evading the off-site problems, is highly desired for precise treatment. Singlet oxygen (1O2) is a highly reactive species used by the biological system as a defensive tool against obnoxious agents and Cancer therapy due to its ready interaction with unsaturated lipids, protein…
(Only some records are available in English at this moment)
Scholarships abroad
- Upconverting nanoparticles for thermometry and singlet oxygen sensing applications in biological imaging, BE.EP.PD
Abstract
Trivalent rare earth ions (RE3+) doped nanoparticles can exhibit upconversion phenomenon. This process consists in excitation of the material with two or more photons and, subsequently, emission of a higher energy photon. In this way, it is possible to use an excitation source in the biological window region and obtain UV-Visible-NIR emissions. The advantages of upconverting nanoparticles…
Total / Available in English
| 18 / 13 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 33 / 12 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 55 / 29 | All research grants and scholarships |
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