Abstract
We have investigated the reactions of beta-carotene and two of its oxidation products, retinal and beta-apo-8'-carotenal, with 2'-deoxyguanosine to evaluate their DNA damaging potential. A known mutagenic adduct, 1,N2-etheno-2'-deoxyguanosine, was isolated and characterized on the basis of its spectroscopic features. After treatment of calf thymus DNA with beta-carotene or beta-carotene o…