CV Lattes
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Universidade de São Paulo (USP). Instituto de Física (IF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Física Biológica from Universidade Estadual Paulista Júlio de Mesquita Filho (2007), master's at Física (Conceito CAPES 7) from Universidade de São Paulo (2010) and doctorate at Física (Conceito CAPES 7) from Universidade de São Paulo (2015). Has experience in Byophysics, focusing on Molecular Biophysics, acting on the following subjects: light scattering, line tension, dmpg, asymmetric bilayers and domain sizes. (Source: Lattes Curriculum)
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We will create in vitro models for cell membranes and engineer lipid bilayers, with each leaflet having a distinct lipid composition yet coupled as a bilayer. The proposed leaflet compositions are designed to emulate the structural characteristics of the exoplasmic and cytoplasmatic leaflets of the plasma membrane. We will use the hemifusion method to create these bilayers. In our model, …
The plasma membrane is a very complex system that provides cellular protection and maintenance. This membrane is composed of a lipid bilayer, with leaflets of asymmetric lipid composition, where proteins are sorted in a lipid matrix of hundreds of lipids. The exoplasmic leaflet has a lipid composition that includes high melting (HTm) lipids, which enable coexistence of liquid phases ("lip…
The plasma membrane (PM) comprises a lipid bilayer composed of two leaflets with distinct lipid compositions, commonly described as an asymmetric bilayer. Phosphatidylserine (PS) is a negatively charged lipid retained in the inner leaflet of the PM in healthy cells. Exposing the lipid PS to the exoplasmic leaflet leads to a cascade of events that signal apoptosis. Cancer cells also displa…
Formed by hundreds of lipids, proteins, and glycoproteins, cellular membranes represent more than a physical barrier to preserve the internal content from the outside environment. The lipid matrix of cellular membranes comprises various lipids with different chemical structures and physicochemical properties. In particular, the plasma membrane (PM)(eukaryotic) has an exoplasmic leaflet en…
The plasma membrane is asymmetric, meaning each leaflet has a distinct lipid composition and phase behavior. The loss of membrane asymmetry might be a crucial difference between health and disease. Cancer cells exhibit phosphatidylserine (PS) asymmetry loss, meaning that PS lipids, found in healthy cells on the PM inner leaflet, are exposed to the exoplasmic leaflet, signaling apoptosis (…
The plasma membrane is asymmetric in terms of lipid composition, meaning that the inner and the outer leaflets have different mixtures of lipids. With the advance of new methods and techniques, asymmetric lipid bilayers can be created in vitro, with controlled compositions. Here, we propose to explore the potential of creating asymmetric giant unilamellar vesicles (aGUVs) using the hemif…
The present Project complements the PhD Project (FAPESP 2010/11671-5), extending it to the study of the interaction of antimicrobial peptides with more complex model membranes, those which contain lipid domains, sometimes called "rafts". This is in line with the presence of non-uniform mixing of lipids in biological membranes. The functional lipid raft was found to be related to the cell …
| 2 / 2 | Ongoing grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 3 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 9 / 9 | All research grants and scholarships |
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