Paulo Jose Ferreira Tucci

• Abstract

  The project aims at investigating the relevant aspects involved in the pathophysiology of Congestive Heart Failure (CHF). Seven subprojects will be part of the CHF experimental model induced in rats after myocardial necrosis. As a whole, the project includes: three subprojects to investigate the effects of prolonged use of digitoxin after myocardial infarction. One of them will conduct fu…

  The pathophysiology of congestive heart failure: from the organ to tile molecules, AP.TEM

• Abstract

  Myocardial infarction (MI) induced in the rat is the most utilized experimental model for myocardial remodeling and heart failure studies. High immediate mortality and MI size high variability are two disadvantages of this method. We aim to standardize the MI induction in the rat by radio-frequency ablation. In preliminary studies we showed that myocardial ablation allows MI very homogene…

  Ventricular ablation: a new method to induce uniforme and low mortality myocardial infarction in the rat, AP.R

• Abstract

  The project includes two sub-projects aiming to evaluate: 1) the physiological bases of the Frank-Starling mechanism studied in isolated dog hearts; 2) the influence of the infarctectomy on the cardiac performance of rat hearts with largo myocardium infarctions. The first sub-project returns to a line of investigation in which the coordinator has already worked and which will be settled i…

  Physiology and physiopathology in cardiology, AP.TEM

(Only some records are available in English at this moment)