CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Universidade de São Paulo (1990), master's at Genetics from Universidade de São Paulo (1994) and doctorate at Genetics from Universidade de São Paulo (1998). Has experience in Biochemistry, focusing on Biochemetry of the Microorganisms, acting on the following subjects: leptospira, matriz extracelular, leptospira interrogans, evasão imune and regulação da transcrição. (Source: Lattes Curriculum)
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Bacteria of the genus Leptospira are spirochetes that have efficient strategies for dissemination in the host. The mechanisms underlying the entry, dissemination, persistence and tissue damage resulting from infection by pathogenic leptospires are still poorly known, but studies carried out by our group have shown that extracellular proteases produced by these bacteria contribute to the d…
Bacteria of the genus Leptospira are spirochetes equipped with efficient strategies for dissemination in the host. Pathogenic species belonging to this genus cause leptospirosis, which can manifest as an acute, chronic or asymptomatic illness, mainly in reservoir hosts, such as mice and rats. About 10 to 20% of cases in humans can evolve to severe forms, leading to shock and death. In thi…
Leptospires are highly invasive spirochetes equipped with efficient strategies for dissemination in the host. Recently we demonstrated that pathogenic leptospires secrete proteases capable of cleaving and inactivating key molecules of the complement system, extracellular matrix and human plasma. In this project we intend to broaden the scope of investigation of possible targets of proteas…
(Only some records are available in English at this moment)
Proteases are among the virulence determinants of a number of medically important pathogens. During the infectious process, pathogens produce proteases that may cleave peptide bonds, leading to irreversible structural changes, in addition to causing tissue damage and excessive inflammation. The mechanisms underlying entry, dissemination, persistence and tissue damage resulting from infect…
Spirochetes belonging to the genus Leptospira are bacteria that cause leptospirosis. Highly mobile, pathogenic leptospires penetrate the host through abrasions on the skin or mucous membranes and quickly reach the target organs. Kidneys are considered as an immunoprivileged site in leptospirosis, given the tropism and the persistence of these spirochetes in this organ. A few studies sugge…
Pathogenic Leptospira species are extremely efficient in disseminating in the host, a fact attributed to their ability to escape complement system activation - the first line of defense of the innate immune response - and also to the ability to degrade extracellular matrix and other components of the human plasma. The secretion of proteases that inactivate host proteins is an important to…
Pathogenic Leptospira species are extremely efficient in disseminating and propagating in the host, a fact attributed to their ability to escape the action of the complement system, the first line of defense of the innate immune response, and also to the ability to degrade components of the extracellular matrix and human plasma. The secretion of proteases that inactivate host proteins is …
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 13 / 11 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 13 / 7 | Completed scholarships in Brazil |
| 28 / 20 | All research grants and scholarships |
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