Abstract
Lameness is a highly prevalent condition in horses and the principal cause of removal from athletic activity. Synovitis or arthritis in horses is frequently treated by administration of non-steroidal inflammatory drugs (NSAIDs) which inhibit cyclooxygenase isoforms (COX -1 and COX-2). Constitutively expressed COX-1 is involved in physiologic functions, such as the maintenance of gastric m…