André Machado Xavier

Graduated in Biological Sciences from the State University of Londrina (2009), with a master's degree (FAPESP, 2012) and a Ph.D. (CNPQ, 2017) in Sciences (Molecular Biology) from the Federal University of São Paulo. During the Ph.D., studied and described a subpopulation of sensory neurons in the olfactory epithelium that express CD36. Completed a Postdoctoral Fellowship in Neuroimmunology and Neurogenomics at Université Laval (2018-2021), where studied and characterized microglia, the resident immune cells of the nervous system, during local and systemic inflammatory processes using animal models of multiple sclerosis (Cuprizone) and intraperitoneal injection of Lipopolysaccharide (LPS) from gram-negative bacteria. From 2021 to 2023, was part of the postdoctoral team at Cold Spring Harbor Laboratory, researching the contribution of microglia during the development of the visual system in mice through single-cell genomic sequencing. Participated in the Institutional Program for Internationalization (CAPES-PrInt, 2024) as a postdoc in the Functional Neurogenomics Laboratory (UNIFESP), where he contributed to the development of a model for presbyosmia using animals deficient in the KLOTHO protein. Currently, a Postdoctoral Researcher in the Molecular Neuroscience Laboratory at IQ-USP (Programa Fixação de Jovens Doutores CNPQ/FAPESP, 2024), studying lipid dynamics in the olfactory cilia of rodents and their importance in olfactory receptor function. Has been mentoring undergraduate, master's, and Ph.D. students associated with Molecular Biology Graduate Programs (CAPES 7) and research institutes CHUL (Université Laval) and CSHL. Experienced in high-density data analysis applied to genomic and epigenomic techniques such as bulk RNA-seq, single-cell/single-nuclei RNA-seq, ChIP-seq, ATAC-seq, histological techniques for multiple spatial gene characterization through traditional In situ Hybridization, RNAscope Hi-Plex, and Flow Cytometry for cell population characterization and isolation of specific central nervous system cells. (Source: Lattes Curriculum)