Decio dos Santos Pinto Junior

• Second World Congress of the International Academic of Oral Oncology, AR.EXT

• Abstract

  Several genetic alterations are related to squamous cell carcinoma (SCC) pathogenesis, the most frequent malignancy in head and neck. Some of these alterations are involved in AKT signaling pathway associated in several cellular events. COX 2 protein initially described in inflammation is also related with AKT pathway. This study aims to verify the pAKT, NF-kB, IKB, mTOR, ciclyn D1 e COX-…

  Expression analysis of the transcripts and proteins COX-2, AKT, NFKB, IKB, MTOR and CD1 in cell cultures of Head and Neck squamous cell carcinomas treated by CELECOXIB, AP.R

• Abstract

  Head and neck squamous cell carcinoma (HNSCC) represents 90% of all head and neck malignancies. Cancer growth, invasion and metastasis are due to several signaling pathways that, unfortunately, are not completely understood. The aim of this study will be the crosstalk evaluation between PTEN, Akt, Mdm2 and p53 signaling pathways in four different HNSCC cell lines (HN6, HN19, HN30 and HN31…

  Evaluation between PTEN, Akt, Mdm2 and p53 signaling pathways in different HNSCC cell lines treated with epidermal growth factor and 17-AAG, AP.R

(Only some records are available in English at this moment)