CV Lattes
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Secretaria de Desenvolvimento Econômico (São Paulo - Estado). Instituto de Pesquisas Energéticas e Nucleares (IPEN) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated at Veterinary Medicine from the State University of Londrina (1984), a master's degree in Biological Sciences (Molecular Biology) from the Federal University of São Paulo (1994) and a PhD in Biological Sciences (Molecular Biology) from the Federal University of São Paulo (2001). She is currently a researcher at the Institute for Energy and Nuclear Research. He has experience in the area of #8203;#8203;cellular and molecular biology of cancer. working mainly on the following topics: Essential elements and cancer metabolism, cell death, development of animal models in oncology. (Source: Lattes Curriculum)
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The renal cell carcinoma (RCC) accounts for approximately 2-3% of human malignancies and, among urologic tumors, it is the most aggressive. The biological heterogeneity, drug resistance and side effects to chemotherapy are the biggest obstacles to effective treatment of RCC. Several molecules have been identified as responsible for the aggressive phenotype of this tumor, one being the NF-…
Renal cell carcinomas (RCCs) comprise 2 to 3% of all human cancers and are the most aggressive of all urological cancers. The most common form of RCC is the clear-cell renal cell carcinoma (RCCcc) that is characterized by frequent inactivation of the von Hippel-Lindau (VHL) gene. Loss-of-function mutations in VHL lead to transcriptional up-regulation of multiple angiogenic factors. Nuclea…
Renal cell carcinoma (RCC) accounts for approximately 2 to 3% of human malignant tumors and it is the most aggressive urological tumor. The most frequent subtype of RCC is the clear cell (ccRCC) one. Most of the patients with ccRCC have a mutation in the Von Hippel-Lindau (VHL) tumor suppressor gene. The inactivation of the VHL gene interrupts the normal regulation of HIF, leading to alte…
Prostate cancer (PCa) is the second leading cause of death in adult men. Age is an important risk factor for PCa, since both incidence and mortality significantly increase after 50 years of age. Early diagnosis of the disease is performed by routine clinical and laboratory tests. The joint analysis of these tests will determine which imaging tests will be necessary to finalize the diagnos…
The renal cell carcinoma (RCC) represents approximately 2 to 3% of human malignant tumors and is the most aggressive of urologic tumors. The most common is the subtype of RCC clear cell (ccRCC). Most patients have mutated gene tumor suppressor in von Hippel-Lindau (VHL) which results in increased transcription of several angiogenic factors such as vascular endothelial growth factor (VEGF)…
(Only some records are available in English at this moment)
Immuno suppressive effect is different for several diseases and involves released growth factors and cytokines depending on tumor context. The tumor microenvironment is orchestrated by different cells that may promote an important immune-evading mechanism. Studies have identified MDSC as potent suppressors of tumor immunity and, therefore, a significant impediment to cancer immunotherapy.…
| 7 / 3 | Completed research grants |
| 13 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 21 / 11 | All research grants and scholarships |
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