Renata de Almeida Coudry

• Abstract

  Colorectal cancer (CRC) is one of the most common malignancies in industrialized countries and major cause of cancer death in the world. Recently a new pathway has been shown to be important in the evolution of CRC, the call via serrated. This pathway is characterized by the presence of hypermethylation of CpG sequences in the promoter region of certain genes, called methylator phenotype …

  Evaluation of the effectiveness of morphological, demographic, endoscopic and molecular the distinction of serrated lesions of the colon and rectum, AP.R

• Abstract

  Anal câncer is a rare neoplasm, but is increasing in incidence with currently estimated at 1.4 per 100,000 men and 1.7 per 100,000 women. There is evidence that the main risk factors for cancer of the anal canal are persistently infected by HPV (human papillomavirus), immunosuppression by HIV infection and smoking. In other types of solid tumors, like colon cancer, are known biomarkers th…

  Expression profile of biomarkers in anal canal carcinoma and correlation with failed treatment with chemo-radiotherapy, AP.R
• Sessile serrated adenoma: another precursor to colon carcinoma., AR.EXT

(Only some records are available in English at this moment)

• Abstract

  TP53 gene is located in the short arm of the chromosome 17 and encodes a protein that prevents cells from accumulating DNA damage by induction of pathways leading to cell arrest or apoptosis. TP53 mutations are found in approximately 50% of human cancers. While most of tumor suppressor genes are inactivated by mutation leading to absence of protein synthesis, more than 80% of TP53 alterat…

  Expression profiling in sporadic adenomas of the colorectum and its correlation with K-ras and BRAF mutation, hMLH1 and MGMT methylation and protein expression of DNA gene repair, BP.DR