CV Lattes
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Universidade Paulista (UNIP). Instituto de Ciências da Saúde (ICS) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Medicina Veterinária from Universidade Estadual de Londrina (1986), master's at Veterinary Medicine from Universidade de São Paulo (1993) and ph.d. at Veterinary Medicine from Universidade de São Paulo (1998). Has experience in Veterinary Medicine, focusing on parasite-host relationship, acting on the following subjects: microsporidia, encephalitozoon cuniculi and camundongos. (Source: Lattes Curriculum)
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Microsporidia are recognized as opportunistic pathogens in individuals with immunodeficiency, especially T-cells deficient. Although CD8 T lymphocyte activity is essential for eliminating these pathogens, macrophages and others innate immunity cells play a critical role in activating adaptive immunity. B-1 cells are a key component in innate immune response against pathogens, but their pa…
The research group (Alvares-Saraiva et al., 2015) demonstrated, for the first time, a regulatory role of B-1 lymphocytes in the control of glycemia in type I diabetes streptozotocin (STZ)-induced. As the main point, the adoptive transfer of B-1 lymphocytes from WT mice to XID mice (deficient in B-1 lymphocytes) has become them resistant to diabetes induction. Also, insulin-producing cells…
The microsporidia infect vertebrates and invertebrates and are known as opportunistic agents in immunedeficiencies patients. Although T CD8 + lymphocyte activity is essential to eliminate the microsporidia, macrophages play a critical role in innate and acquired immunity activation. For some infectious agents, the polarization of M1 and M2 macrophages is crucial in setting the direction t…
(Only some records are available in English at this moment)
The microsporidia of the Encephalitozoon species infect a wide variety of mammals and are opportunistic agents in immunosuppressed patients, such as HIV+ patients, as well as in other therapeutic or genetic conditions. In these cases, the disseminated infection determines death due to the lack of effective therapy. The adaptive immune response is essential for the elimination of these pat…
| 1 / 0 | Ongoing grants |
| 7 / 5 | Completed research grants |
| 2 / 1 | Completed scholarships in Brazil |
| 10 / 6 | All research grants and scholarships |
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