CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
MS (1992) and PhD (1995) in Physiology from Universidade Federal de São Paulo. Currently Professor (2012-) at the Biomedical Sciences Institute, Universidade of São Paulo. Has experience in Cell and Molecular Biology, focusing in key aspects of muscle plasticity such as regeneration, hypertropy/atrophy and hormonal action in muscle. (Source: Lattes Curriculum)
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Proper functioning of skeletal muscle tissue plays a crucial role in maintaining homeostasis. Furthermore, conditions that result in significant loss of skeletal muscle mass are associated with highly relevant clinical conditions, such as joint injuries and sarcopenia. It is well known that sarcopenic individuals have an increased chance of death when undergoing surgical procedures, and i…
It is known that the elastic deformation imposed on bones by muscle contraction stimulates bone formation, while inhibiting resorption, which favors the gain of bone mass. Considering that bone and skeletal muscle tissues secrete factors (osteokines and myokines, respectively) that act in other tissues or organs via paracrine and endocrine mechanisms, a new paradigm has been established t…
Skeletal muscle dysfunction results in inadequate control of homeostasis and particularly a significant skeletal muscle loss (sarcopenia) has a substantial negative impact in the senile fragility syndrome onset in aging. This syndrome is characterized by an increased mortality due an individual's lower ability to maintain vital functions and typical immunological response. Furthermore, we…
This project contains a series of proposals aiming to deepen the knowledge on cellular and molecular mechanisms that control skeletal muscle mass and regeneration. This knowledge is key to the future development of therapeutic strategies that can improve skeletal muscle viability, consequently increasing quality of life. Noteworthy, there are a number of key clinical conditions involving …
(Only some records are available in English at this moment)
Prolonged mechanical ventilation induces diaphragmatic atrophy and dysfunction, a progressive clinical condition with rapid onset, which is often associated with ventilation weaning failure and high mortality in critical ill patients. The comprehension of the biological mechanisms involved in ventilator-induced diaphragmatic atrophy and dysfunction is essential to the development of effec…
Pulmonary emphysema is a chronic and progressive inflammatory disease that causes dyspnea, exercise capacity limitation, sarcopenia and weight loss that affects 17% of the population in Brazil and 10% of the adult population in industrialized countries. The present study aims to evaluate the effect of a selective inhibitor of MuRF1 activity (Muscle-RING Finger Protein 1), the compound Myo…
(Only some records are available in English at this moment)
Mechanical ventilation (MV) is a life-saving intervention commonly used in intensive care units (ICUs) for patients who cannot independently maintain adequate gas exchange. However, long-term MV results in detrimental clinical effects, including skeletal muscle weakness and wasting. Ventilator-induced diaphragmatic dysfunction (VIDD) is the early and progressive loss of diaphragm muscle c…
Heart Failure with preserved ejection fraction (HFpEF, approximately 50% of all heart failure (HF) cases) is a complex syndrome, with high morbidity and mortality rates. This form of HF is frequently seen in patients suffering from co-morbidities associated with the metabolic syndrome, namely obesity, hypertension, diabetes mellitus and hyperlipidemia, suggesting that HFpEF is a systemic …
Skeletal muscle is a major target of thyroid hormone (T3), this hormone acts mainly through gene transcription modulation and it is known for inducing muscle proteolysis. Previously, we addressed the effects of T3 in the protein synthesis and degradation related pathways by microarray analysis. From these data, we have shown that high levels of T3 stimulate protein breakdown by ubiquitin-…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 22 / 9 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 39 / 16 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 70 / 34 | All research grants and scholarships |
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