Abstract
Streptococcus pneumoniae is a common respiratory pathogen worldwide. The pneumococcal 7-valent conjugate (PCV7, including serotypes 4, 9V, 6B, 14, 18C, 19F and 23F) was licensed in the U.S. and Europe, showing a significant impact in reducing invasive disease caused by vaccine serotypes of pneumococcus. In Brazil, the National Immunization Program in 2010 included the 10-valent conjugate …