Abstract
The co-chaperone STI1 (stress inducible protein 1) or Hop (Hsp70/Hsp90 organizing protein) herein denominated STI1/Hop, was characterized as a prion protein (PrPC) specific ligand. This interaction modulates a number of functions such as protection against apoptosis and neuritogenesis in hippocampal neurons. STI1/Hop is abundantly expressed in cytoplasm but binds PrPC outside of the cell …