Abstract
The prevention and treatment of pain in animals is very important as pain produces several undesirable effects. Studies to develop improved techniques for pain management deserve attention. Methadone besides being a ¼ agonist, is a antagonist of N-methyl D-aspartate receptor (NMDA) and inhibits norepinephrine reuptake, which could contribute to a more efficient analgesia. Nanoparticles of…