Cesar Costapinto Santana

• Abstract

  The aim of the proposal is the integration of modern technologies for the construction and application of biologically active molecules. The potential of simulated moving bed systems for racemic mixtures separation and purification will be explored aiming at the integration with synthetic organic chemistry. Relatively simple synthetic schemes will be applied and the key-intermediates race…

  Application of simulated moving beds with variable zone lenght (Varicol) for the obtention of enantiomers of biologically active compounds, AP.TEM
• Continuous chromatographic separation of n-boc-baclofen-lactam in a simulated moving bed using polysaccharide carbamate as the chiral stationary phase., AR.EXT
• Separation of the anesthetic ketamine enantiomers using simulated moving bed chromatography, AR.EXT

(Only some records are available in English at this moment)

• Abstract

  The continuous chromatography with simulated moving bed (SMB) technology has been used with increasing success for the separation of binary mixtures of high valued compounds. The combination of this technology with high capacity and high selectivity stationary phases turns the SMB a highly competitive process, including for commercial purposes. Due to the complex design of these SMB uni…

  Design of experiments and optimization of operating conditions in a simulated moving bed: application in chiral drugs separation, BP.PD