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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dependence of optical attenuation coefficient and mechanical tension of irradiated human cartilage measured by optical coherence tomography

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Author(s):
Martinho, Jr., A. C. [1] ; Freitas, A. Z. [1] ; Raele, M. P. [1] ; Santin, S. P. [1] ; Soares, F. A. N. [1] ; Herson, M. R. [2] ; Mathor, M. B. [1]
Total Authors: 7
Affiliation:
[1] CNEN SP, IPEN, Sao Paulo - Brazil
[2] Monash Univ, Alfred Skin Cell Culture Lab, Melbourne, Vic 3004 - Australia
Total Affiliations: 2
Document type: Journal article
Source: CELL AND TISSUE BANKING; v. 15, n. 3, p. 337-343, SEP 2014.
Web of Science Citations: 2
Abstract

As banked human tissues are not widely available, the development of new non-destructive and contactless techniques to evaluate the quality of allografts before distribution for transplantation is very important. Also, tissues will be processed accordingly to standard procedures and to minimize disease transmission most tissue banks will include a decontamination or sterilization step such as ionizing radiation. In this work, we present a new method to evaluate the internal structure of frozen or glycerol processed human cartilages, submitted to various dosis of irradiation, using the total optical attenuation coefficient retrieved from optical coherence tomography (OCT) images. Our results show a close relationship between tensile properties and the total optical attenuation coefficient of cartilages. Therefore, OCT associated with the total optical attenuation coefficient open a new window to evaluate quantitatively biological changes in processed tissues. (AU)

FAPESP's process: 08/10437-9 - Study of ionizing radiation effects in human costal cartilage by Termogravimetry and Optical Coherence Tomography
Grantee:Monica Beatriz Mathor
Support Opportunities: Regular Research Grants