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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Analysis of FokI Polymorphism of Vitamin D Receptor Gene in Intervertebral Disc Degeneration

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Vieira, Luiz Angelo [1] ; De Marchi, Patricia Leme [2] ; dos Santos, Aline Amaro [1] ; Christofolini, Denise Maria [2] ; Barbosa, Caio Parente [2] ; Affonso Fonseca, Fernando Luiz [3] ; Bianco, Bianca [2] ; Rodrigues, Luciano Miller R. [1]
Total Authors: 8
[1] Fac Med ABC, Dept Surg, Div Orthoped & Traumatol, BR-09060650 Santo Andre, SP - Brazil
[2] Fac Med ABC, Ctr Human Reprod & Genet, Dept Gynecol & Obstet, Genet Lab, BR-09060650 Santo Andre, SP - Brazil
[3] Fac Med ABC, Dept Clin Med, Lab Clin Anal, BR-09060650 Santo Andre, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: GENETIC TESTING AND MOLECULAR BIOMARKERS; v. 18, n. 9, p. 625-629, SEP 2014.
Web of Science Citations: 20

Aim: We have hypothesized a possible relationship between disc degeneration (DD) and VDR FokI/T2C polymorphism. Methods: A case-control study was performed comprising 121 Brazilian patients with confirmed DD by nuclear magnetic resonance and a control group consisting of 131 healthy patients without a history of disc cysts of the lumbar spine. Detection of VDR FokI/T2C polymorphism was performed using restriction fragment length polymorphism-polymerase chain reaction. The chi-square test was used to compare allele and genotype frequencies between groups, and a p-value of < 0.05 was considered statistically significant. Results: The results disclosed statistical difference between allele distribution among cases and controls (p = 0.025, odds ratio = 1.58, confidence interval = 1.07-2.32) considering VDR FokI/T2C polymorphism. Conclusion: The results showed a positive association between VDR FokI/T2C polymorphism and DD in Brazilian patients tested. (AU)

FAPESP's process: 12/21886-4 - Evaluation of the frequency of thepolymorphism fok1 of Vitamin D receptor (gene (VDR) in the etiology of disc degeneration
Grantee:Patricia Leme de Marchi
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/00902-4 - Evaluation of the frequency of polymorphisms of Vitamin D receptor gene(VDR) as a risk factor in the etiology of disc degeneration
Grantee:Luciano Miller Reis Rodrigues
Support type: Regular Research Grants