Pilot study testing the effect of physical training over the myocardial perfusion and quality of life in patients with primary microvascular angina

Author(s):Show less -

Vieira de Carvalho, Eduardo Elias ^[1] ; Santi, Giovani Luiz ^[1] ; Crescencio, Julio Cesar ^[1] ; Lemos de Oliveira, Luciano Fonseca ^[1] ; Costa dos Reis, Daniela Caetano ^[1] ; Figueiredo, Alexandre Baldini ^[1] ; Pintya, Antonio Osvaldo ^[1] ; Lima-Filho, Moyses Oliveira ^[1] ; Gallo-Junior, Lourenco ^[1] ; Marin-Neto, Jose Antonio ^[1] ; Simoes, Marcus Vinicius ^{[1, 2]}

Affiliation

^[1] Hosp Clin Sao Paulo, Fac Med Ribeirao Preto, Dept Internal Med, Div Cardiol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Med Sch Ribeirao Preto, Div Cardiol, Dept Internal Med, BR-14049 Ribeirao Preto - Brazil

• Document type: Journal article
• Source: JOURNAL OF NUCLEAR CARDIOLOGY; v. 22, n. 1, p. 130-137, FEB 2015.
• Web of Science Citations: 1

Abstract

Primary microvascular angina (PMA) is a common clinical condition associated to negative impact on quality of life (QOL) and reduced physical capacity. This study aimed at evaluating the effects of aerobic physical training (APT) on myocardial perfusion, physical capacity, and QOL in patients with PMA. We investigated 12 patients (53.8 +/- A 9.7 years old; 7 women) with PMA, characterized by angina, angiographycally normal coronary arteries, and reversible perfusion defects (RPDs) detected on Tc-99m-sestamibi-SPECT myocardial perfusion scintigraphy (MPS). At baseline and after 4 month of APT, the patients underwent MPS, cardiopulmonary test, and QOL questionnaire. Stress-rest MPS images were visually analyzed by attributing semi-quantitative scores (0 = normal; 4 = absent uptake), using a 17-segment left ventricular model. Summed stress, rest, and difference scores (SDS) were calculated. In comparison to the baseline, in the post-training we observed a significant increase in peak-VO2 (19.4 +/- A 4.8 and 22.1 +/- A 6.2 mL center dot kg(-1)center dot minute(-1), respectively, P = .01), reduction of SDS (10.1 +/- A 8.8 and 2.8 +/- A 4.9, P = .008), and improvement in QOL scores. Physical training in patients with PMA is associated with reduction of myocardial perfusion abnormalities, increasing of physical capacity, and improvement in QOL. The findings of this hypothesis-generating study suggest that APT can be a valid therapeutic option for patients with PMA. (AU)

• FAPESP's process: 08/04140-3 - Study of the correlation between the extent of myocardial sympathetic denervation and arrhythmic events in patients with chronic Chagas cardiomyopathy
• Grantee: Marcus Vinicius Simões
• Support Opportunities: Regular Research Grants