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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Interleukin 17A Acts Synergistically With Interferon gamma to Promote Protection Against Leishmania infantum Infection

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Lima Nascimento, Manuela Sales [1] ; Carregaro, Vanessa [1] ; Lima-Junior, Djalma Souza [1] ; Costa, Diego Luis [1] ; Ryffel, Bernhard [2, 3] ; Duthie, Malcolm S. [4] ; de Jesus, Amelia [5] ; de Almeida, Roque Pacheco [5] ; da Silva, Joao Santana [1]
Total Authors: 9
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Aracaju - Brazil
[2] CNRS, F-45071 Orleans - France
[3] Univ Orleans, UMR6218, Orleans - France
[4] Infect Dis Res Inst, Seattle, WA - USA
[5] Univ Fed Sergipe, Ctr Biol & Hlth Sci, Aracaju - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of Infectious Diseases; v. 211, n. 6, p. 1015-1026, MAR 15 2015.
Web of Science Citations: 42

Interleukin 17 (IL-17) is an inflammatory cytokine that plays a protective role against intracellular parasites. The role of IL-17 during Leishmania infection remains controversial and poorly defined. We evaluated whether IL-17 participates in the host immune response to Leishmania infantum. IL-17A is present in sera from patients with visceral leishmaniasis and decreases after successful treatment. In C57BL/6 infected mice, higher production of IL-17A coincided with the peak of parasitism gamma Il17ra(-/-) mice were more susceptible to infection and also exhibited reduced inflammatory infiltration and interferon gamma (IFN-gamma)-expressing CD4(+) T-cell frequencies than wild-type mice. The frequencies of FoxP3(+)CD4(+) T cells and interleukin 10 (IL-10)-expressing CD4(+) T cells were increased in Il17ra(-/-) mice. We also demonstrated that IL-17A acts synergistically with IFN-gamma to potentiate NO production and leishmanicidal activity in infected macrophages. Therefore, our results indicate that L. infantum induces IL-17A production, which promotes the control of parasite replication by strengthening T-helper type 1 responses and NO production and prevents regulatory T-cell and IL-10-expressing T-cell expansion. (AU)

FAPESP's process: 13/01967-2 - Characterization of the mechanisms involved in the generation and modulation of protective immune response during Leishmania infantum infection
Grantee:Manuela Sales Lima Nascimento
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 12/14524-9 - Modulation of T lymphocytes differentiation in infections by Protozoa, Fungi and Bacteria
Grantee:João Santana da Silva
Support Opportunities: Research Projects - Thematic Grants