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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Characterization of Luteal Blood Flow and Secretion of Progesterone in Mares Treated With Human Chorionic Gonadotropin for Ovulation Induction or During Early Diestrus

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Author(s):
Romano, Rafael Mide [1] ; Ferreira, Jair Camargo [1, 2] ; Canesin, Heloisa de Siqueira [1] ; Boakari, Yatta Linhares [1] ; Ignacio, Fernanda Saules [1] ; Novaes Filho, Luiz Fernando [1] ; Thompson, Jr., Donald L. [2] ; de Meira, Cezinande [1]
Total Authors: 8
Affiliation:
[1] UNESP, Sch Vet Med & Anim Sci, Dept Anim Reprod & Vet Radiol, BR-18618970 Botucatu, SP - Brazil
[2] Louisiana State Univ, Ctr Agr, Sch Anim Sci, Baton Rouge, LA 70803 - USA
Total Affiliations: 2
Document type: Journal article
Source: Journal of Equine Veterinary Science; v. 35, n. 7, p. 591-597, JUL 2015.
Web of Science Citations: 3
Abstract

Human chorionic gonadotropin (hCG) has been used to induce ovulation and as a luteotrophic agent in cattle. However, the effect of hCG therapy on the functional status of the equine corpus luteum (CL) is unclear. This study aimed to characterize the hemodynamic and secretory function of early CL of mares treated with different doses of hCG at distinct stages of the estrous cycle. Mares were assigned to nine experimental groups (n = 6 mares/group) according to dose of hCG and time of treatment. A single injection of one of three different doses of hCG (750, 1,500, or 2,500 IU) was performed in one of three distinct stages of the estrous cycle: preovulatory follicle >= 35 mm, day of ovulation (DO), or 48 hours after ovulation (D2). In addition, a control group treated with NaCl 0.9% was included in the study. The end points evaluated daily from DO to D8 were area of the CL, luteal vascularity, number of colored pixels and total pixel intensity, and concentrations of plasma progesterone (P4). No effect (P > .1) of dose or time of treatment was observed for any end point, within each day. Luteal area did not differ throughout the days (P > .1), whereas Doppler parameters and concentrations of plasma P4 presented a progressive increase (P < .05) after ovulation in all groups. Secretory function and luteal hemodynamic were not affected (P > .1) by hCG dose and time of treatment. In conclusion, hCG therapy during estrus or early diestrus, at the doses tested, did not improve P4 secretion or luteal blood flow. (C) 2015 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 11/04744-9 - Influence of human chorionic gonadotropin in low doses and at different moments of the estrous cycle on the hemodynamic of pre-ovulatory follicles and luteal development in mares
Grantee:Rafael Mide Romano
Support type: Scholarships in Brazil - Master