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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Delineating behavioral and cognitive phenotypes in juvenile myoclonic epilepsy: Are we missing the forest for the trees?

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Author(s):
Valente, Kette D. [1, 2, 3, 4] ; Rzezak, Patricia [1, 2, 3] ; Moschetta, Sylvie P. [1] ; de Vincentiis, Silvia [1, 2, 3] ; Coan, Ana C. [5] ; Guerreiro, Carlos A. M. [5]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Med, IPq HC FMUSP, Lab Clin Neurophysiol, Inst Psychiat, BR-01060970 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst & Dept Psychiat, LIM Lab Neuroimaging Neuropsychiat Disorders 21, BR-01060970 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Univ Sao Paulo Appl Neurosci, NAPNA Res Support Ctr, BR-01060970 Sao Paulo, SP - Brazil
[4] IPq HC FMUSP, Psychol & Neuropsychol Unit, Sao Paulo - Brazil
[5] Univ Campinas UNICAMP, Dept Neurol, Sao Paulo, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Epilepsy & Behavior; v. 54, p. 95-99, JAN 2016.
Web of Science Citations: 15
Abstract

Introduction: Patients with juvenile myoclonic epilepsy (JME) have executive dysfunction and impulsive traits. There are lines of evidence that JME is a heterogeneous epilepsy syndrome considering outcome. In this study, we aimed to analyze this heterogeneity beyond seizure control. The objective was to identify whether the pattern of cognitive dysfunction and impulse control is also heterogeneous, in an attempt to establish possible differences in patients with easy-and hard-to-control epilepsies. Methods: Essentially, 57 patients with JME were compared with 44 controls. Patients and controls were assessed with a neuropsychological battery for executive, attention, and memory functions. The expression of impulsive traits was evaluated with the Temperament and Character Inventory - novelty seeking domain. Then, patients were categorized according to seizure control as having easy-and hard-to-control JME. Results: Patients with hard-to-control JME showed worse performance in 12 out of 25 neuropsychological tests than those with easy-to-control JME. Patients with hard-to-control JME also demonstrated significantly higher scores in novelty seeking -subfactor impulsiveness (p=0.002). Significance: Our study demonstrated the existence of distinct or more severe cognitive and psychiatric profiles in a subset of patients with JME. Patients with treatment-refractory seizures seem to present a broader impairment related to both cognitive deficits and impulsive traits. These findings suggest that patients with JME are not equally compromised by executive and memory deficits or dysfunction, neither by their impulsive traits. Thus, there is a need for a better characterization of patients with JME to include diverse phenotypes since our results suggest a possible existence of distinct groups of patients with JME. (C) 2015 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 05/56464-9 - Neuroscience Imaging Center at University of São Paulo Medical School
Grantee:Giovanni Guido Cerri
Support type: Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants
FAPESP's process: 07/52110-3 - Juvenile myoclonic epilepsy: evaluation of attentional and executive functions, personality traits and social adaptation
Grantee:Sylvie Carolina Paes Moschetta
Support type: Scholarships in Brazil - Master