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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinical, behavioral and antinociceptive effects of crotalphine in horses

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Bueno do Prado Guirro, Erica Cristina [1] ; Perotta, Joao Henrique [2] ; de Paula, Marcio [3] ; Cury, Yara [4] ; Araujo Valadao, Carlos Augusto [5]
Total Authors: 5
[1] Univ Fed Parana UFPR, Dept Ciencias Vet, Setor Palotina, Rua Pioneiro 2153, BR-85950000 Palotina, PR - Brazil
[2] Univ Fed Parana UFPR, Dept Med Vet, Setor Agr, BR-85950000 Palotina, PR - Brazil
[3] Consorcio Ind Farmaceut COINFAR, Sao Paulo, SP - Brazil
[4] Inst Butantan, Lab Patofisiol, Sao Paulo, SP - Brazil
[5] Univ Estadual Paulista UNESP, Dept Clin & Cirurgia Vet, Jaboticabal, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Ciência Rural; v. 46, n. 4, p. 694-699, APR 2016.
Web of Science Citations: 0

ABSTRACT: Crotalphine is a novel analgesic peptide that acts on kappa opioid and delta receptors, causing powerful analgesia in rats submitted to inflammatory, neuropathic or oncologic models of pain. This study evaluated clinical, behavioral and antinociceptive effects caused by crotalphine in horses, employing 18 Arabian horses and it was divided in three phases. In Phase I, "clinical and behavioral effects", crotalphine did not change the latency to urinate and defecate; did not modify the values of cardiac or respiratory rates, intestinal motility and rectal temperature; and did not cause significant ataxia, head, eye and lip ptosis. In Phase II, "antinociceptive effect on intact skin at scapular or ischial region", crotalphine did not cause significant analgesia. In Phase III, "antinociceptive effect on incised skin at scapular or ischial region", crotalphine promoted effective antinociceptive effects for six hours and inhibited hyperalgesia state for three days in the ischial region of horses submitted to incisional model of inflammatory pain, but crotalphine did not evoke relevant analgesic effect on the scapular region. Concluding, intravenous injection of a single dose of crotalphine (3.8ngkg-1) did not cause important clinical or behavioral changes and promotes antinociceptive effect on incised ischial region for seven days in horses. Moreover, crotalphine did not evoke relevant anti nociceptive effect on the scapular region or in intact skin of horses. (AU)

FAPESP's process: 05/04480-0 - Evaluation of behavioral, clinical and antinociceptive effects of syntetic factor CNF021.03 obtained from venom of serpents Crotalus durissus terrificus in horses: comparison with morphine, U50-488H and phenylbutazone
Grantee:Carlos Augusto Araújo Valadão
Support Opportunities: Regular Research Grants