Scaffolds and tissue regeneration: An overview of the functional properties of selected organic tissues

Author(s)

Rebelo, Marcia A. ; Alves, Thais F. R. ; de Lima, Renata ; Oliveira, Jr., Jose M. ; Vila, Marta M. D. C. ; Balcao, Victor M. ; Severino, Patricia ; Chaud, Marco V.

• Document type: Review article
• Source: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS; v. 104, n. 7, p. 1483-1494, OCT 2016.
• Web of Science Citations: 3

Abstract

Tissue engineering plays a significant role both in the re-establishment of functions and regeneration of organic tissues. Success in manufacturing projects for biological scaffolds, for the purpose of tissue regeneration, is conditioned by the selection of parameters such as the biomaterial, the device architecture, and the specificities of the cells making up the organic tissue to create, in vivo, a microenvironment that preserves and further enhances the proliferation of a specific cell phenotype. To support this approach, we have screened scientific publications that show biomedical applications of scaffolds, biomechanical, morphological, biochemical, and hemodynamic characteristics of the target organic tissues, and the possible interactions between different cell matrices and biological scaffolds. This review article provides an overview on the biomedical application of scaffolds and on the characteristics of the (bio)materials commonly used for manufacturing these biological devices used in tissue engineering, taking into consideration the cellular specificity of the target tissue. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1483-1494, 2016. (AU)

• FAPESP's process: 13/03181-6 - PneumoPhageKill: development of a therapeutic system containing nanoencapsulated strictly lytic bacteriophages for Pseudomonas aeruginosa, for the treatment of bacterial pneumonia via nebulization
• Grantee: Marta Maria Duarte Carvalho Vila
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/19300-4 - Use of institutional technical reserve for purchase of equipment designated to expansion of infrastructure for research in the Laboratory Development and Evaluation of Bioactive Substances
• Grantee: Fernando de Sá Del Fiol
• Support Opportunities: Research Grants - Technical Reserve for Institutional Research Infrastructure