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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

XPD c.934G > A polymorphism of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma patients treated with cisplatin chemoradiation

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Lopes-Aguiar, Leisa ; Dias Costa, Ericka Francislaine ; Silva Nogueira, Guilherme Augusto ; Penna Lima, Tathiane Regine ; Visacri, Marilia Berlofa ; Pincinato, Eder Carvalho ; Calonga, Luciane ; Mariano, Fernanda Viviane ; de Almeida Milani Altemani, Albina Messias ; Carrasco Altemani, Joao Maurcio ; Coutinho-Camillo, Claudia Malheiros ; Fernandes Ribeiro Alves, Maria Almerinda Vieira ; Moriel, Patricia ; Ramos, Celso Dario ; Chone, Carlos Takahiro ; Passos Lima, Carmen Silvia
Total Authors: 16
Document type: Journal article
Source: ONCOTARGET; v. 8, n. 10, p. 16190-16201, 2017.
Web of Science Citations: 7
Abstract

This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin (CDDP) chemoradiation. Patients with XPC c.2815AC or CC and XPD c.934GA or AA genotypes had 0.20 and 0.38 less chances of presenting moderate/severe ototoxicity and nausea, respectively. Patients with XPD c.934AA and c.2251AC or CC genotypes had 8.64, 12.29 and 3.55 more chances of achieving complete response (CR), consistent ototoxicity and nephrotoxicity, respectively. AA haplotype of XPD and ACT haplotype of XPD and ERCC1 SNPs were associated with 9.30 and 3.41 more chances of achieving CR and consistent nephrotoxicity, respectively. At 24 months of follow-up, patients with XPD c.934AA genotype presented lower progression-free survival and overall survival in Kaplan-Meier estimates, and differences between groups remained the same in univariate Cox analysis. Patients with XPD c.934AA genotype had 2.13 and 2.04 more risks of presenting tumor progression and death than others in multivariate Cox analysis. Our data present preliminary evidence that XPC c.2815A>C, XPD c.934G>A and c.2251A>C, and ERCC1 c.354C>T SNPs alter outcome of HNSCC patients treated with CDDP chemoradiation. (AU)

FAPESP's process: 11/15089-1 - Polymorphisms in DNA Repair Genes in the Pharmacogenetics of Cisplatin Associated with Radiotherapy in Patients with Head and Neck Squamous Cell Carcinoma
Grantee:Leisa Lopes Aguiar
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/01807-2 - Pharmacogenetics of cisplatin in head and neck squamous cell carcinoma
Grantee:Carmen Silvia Passos Lima
Support type: Regular Research Grants