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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Increased mutability to fosfomycin resistance in Proteus mirabilis clinical isolates

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Fonseca, Marina R. B. [1] ; Sato, Juliana L. [1] ; Lima-Noronha, Marco A. [1] ; Migliorini, Leticia B. [1] ; Fernandez-Silva, Frank S. [1] ; Galhardo, Rodrigo S. [1]
Total Authors: 6
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: INFECTION GENETICS AND EVOLUTION; v. 58, p. 27-33, MAR 2018.
Web of Science Citations: 0

In the present study, we screened a collection of 77 Proteus mirabilis clinical isolates for the presence of mutators, using the frequency of both rifampicin and fosfomycin resistance mutants as markers of spontaneous mutagenesis. We found that none of the strains in our collection are mutators for the rifampicin resistance (Rif(R)) marker. Nevertheless, a significant fraction of the isolates (17%) show high frequencies of fosfomycin resistant mutants (Fos(R)). We show that this increased mutability to FosR correlates with a low level of resistance to Fosfomycin (MICs 8-64 mu g/ml). These strains also show high frequencies of single step mutants with clinically relevant FosR resistance levels (MIC >= 256 mu g/ml). Our findings point out to the risk of fosfomycin resistance emergence in P. mirabilis. (AU)

FAPESP's process: 15/11348-3 - Characterization of mutator phenotypes in Proteus mirabilis isolates
Grantee:Marina Rocha Borges da Fonseca
Support type: Scholarships in Brazil - Master