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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Interaction between hippocampal-prefrontal plasticity and thalamic-prefrontal activity

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Author(s):
Bueno-Junior, Lezio S. [1] ; Peixoto-Santos, Jose E. [1] ; Ruggiero, Rafael N. [1] ; Avila, Milton A. V. [1] ; Marques, Danilo B. [1] ; Lopes-Aguiar, Cleiton [2] ; Leite, Joao P. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav Sci, BR-14049900 Ribeirao Preto - Brazil
[2] Univ Fed Minas Gerais, Inst Biol Sci, Dept Physiol & Biophys, Nucleo Neurociencias, BR-31270901 Belo Horizonte, MG - Brazil
Total Affiliations: 2
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, JAN 22 2018.
Web of Science Citations: 4
Abstract

The prefrontal cortex integrates a variety of cognition-related inputs, either unidirectional, e.g., from the hippocampal formation, or bidirectional, e.g., with the limbic thalamus. While the former is usually implicated in synaptic plasticity, the latter is better known for regulating ongoing activity. Interactions between these processes via prefrontal neurons are possibly important for linking mnemonic and executive functions. Our work further elucidates such dynamics using in vivo electrophysiology in rats. First, we report that electrical pulses into CA1/subiculum trigger late-onset (>400 ms) firing responses in the medial prefrontal cortex, which are increased after induction of long-term potentiation. Then, we show these responses to be attenuated by optogenetic control of the paraventricular/mediodorsal thalamic area. This suggests that recruitment and plasticity of the hippocampal-prefrontal pathway is partially related to the thalamic-prefrontal loop. When dysfunctional, this interaction may contribute to cognitive deficits, psychotic symptoms, and seizure generalization, which should motivate future studies combining behavioural paradigms and long-range circuit assessment. (AU)

FAPESP's process: 16/17882-4 - Drug-resistant epilepsies: diagnostic challenges, associated comorbidities and new experimental approaches
Grantee:João Pereira Leite
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 15/20840-9 - Histopathological correlates of magnetic resonance imaging in patients with drug-resistant epilepsies
Grantee:José Eduardo Peixoto Santos
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/18211-0 - Characterization and optogenetic control of the hippocampus-medial prefrontal cortex interplay during the post-learning sleep in an experimental model of early-life seizures
Grantee:Cleiton Lopes Aguiar
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 12/06123-4 - Hippocampal-prefrontal synaptic plasticity in awake rats: effects of thalamic stimulation during natural sleep and implications for memory consolidation
Grantee:Lézio Soares Bueno Júnior
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 12/23918-0 - Synaptic plasticity of the hippocampus-prefrontal cortex pathway and its relations with behavioral and molecular changes in rats submitted to febrile seizures during development
Grantee:Rafael Naime Ruggiero
Support Opportunities: Scholarships in Brazil - Doctorate