Cocaine-induced behavioral sensitization is greate... - BV FAPESP
Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cocaine-induced behavioral sensitization is greater in adolescent than in adult mice and heightens cocaine-induced conditioned place preference in adolescents

Full text
Author(s):
Camarini, Rosana [1] ; Hoffmann, Lucas Barbosa [1] ; Suarez, Andrea [2] ; Rae, Mariana [1] ; Marcourakis, Tania [3] ; Pautassi, Ricardo Marcos [2]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Farmacol, Av Prof Lineu Prestes 1524, BR-05508900 Sao Paulo - Brazil
[2] Univ Nacl Cordoba, CONICET, INIMEC, Inst Invest Med Mercedes & Martin Ferreyra, Friuli 2434, RA-5000 Cordoba, Pcia De Cordoba - Argentina
[3] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Av Prof Lineu Prestes, 580 B1 13B, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Pharmacology Biochemistry and Behavior; v. 181, p. 60-68, JUN 2019.
Web of Science Citations: 0
Abstract

Adolescents are more sensitive than adults to the neural and behavioral effects of psychostimulants, and exhibit greater vulnerability to drug abuse, dependence or relapse into these conditions. We have reported that cocaine pretreatment during adolescence promotes the expression of behavioral sensitization to a greater extent than when the pretreatment occurs at adulthood. Behavioral sensitization has been associated to the transition from drug use to addiction and is postulated to indicate heightened sensitivity to the appetitive motivational effects of drugs. The relationship between behavioral sensitization and conventional measures of drug reward, such as conditioned place preference (CPP), has yet to be thoroughly investigated, and little is known about age-related differences in this phenomenon. The present study tested cocaine-induced CPP in adolescent and adult mice exposed to cocaine (or vehicle) pretreatment, either in an intermittent or ``binge{''} (i.e., heavy cocaine use on a single occasion, which increases the likelihood of experiencing cocaine-related problems) fashion. Cocaine administration induced behavioral sensitization to a greater extent in adolescent than in adult mice. Cocaine induced CPP was fairly similar in vehicle pretreated adolescent and adult mice, yet greater in adolescent vs. adults after cocaine-induced sensitization. The results confirmed the higher sensitivity of adolescent mice to cocaine-induced behavioral sensitization and suggest its association with greater sensitivity to cocaine's rewarding effects. (AU)

FAPESP's process: 17/11987-1 - Transgenerational epigenetic inheritance and environmental enrichment in male mice: investigation of hippocampus-dependent behaviors in the offspring and the involvement of epididymosomes
Grantee:Lucas Barbosa Hoffmann
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 12/10260-7 - Evaluation of CREB activation pathway in adolescent and adult mice treated with cocaine.
Grantee:Rosana Camarini
Support Opportunities: Regular Research Grants