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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Modulation of hypercapnic respiratory response by cholinergic transmission in the commissural nucleus of the solitary tract

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Furuya, Werner I. [1] ; Bassi, Mirian [1] ; Menani, Jose V. [1] ; Colombari, Eduardo [1] ; Zoccal, Daniel B. [1] ; Colombari, Debora S. A. [1]
Total Authors: 6
[1] UNESP Sao Paulo State Univ, Sch Dent, Dept Physiol & Pathol, Araraquara, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Web of Science Citations: 0

The nucleus of the solitary tract (NTS) is an important area of the brainstem that receives and integrates afferent cardiorespiratory sensorial information, including those from arterial chemoreceptors and baroreceptors. It was described that acetylcholine (ACh) in the commissural subnucleus of the NTS (cNTS) promotes an increase in the phrenic nerve activity (PNA) and antagonism of nicotinic receptors in the same region reduces the magnitude of tachypneic response to peripheral chemoreceptor stimulation, suggesting a functional role of cholinergic transmission within the cNTS in the chemosensory control of respiratory activity. In the present study, we investigated whether cholinergic receptor antagonism in the cNTS modifies the sympathetic and respiratory reflex responses to hypercapnia. Using an arterially perfused in situ preparation of juvenile male Holtzman rats, we found that the nicotinic antagonist (mecamylamine, 5 mM), but not the muscarinic antagonist (atropine, 5 mM), into the cNTS attenuated the hypercapnia-induced increase of hypoglossal activity. Furthermore, mecamylamine in the cNTS potentiated the generation of late-expiratory (late-E) activity in abdominal nerve induced by hypercapnia. None of the cholinergic antagonists microinjected in the cNTS changed either the sympathetic or the phrenic nerve responses to hypercapnia. Our data provide evidence for the role of cholinergic transmission in the cNTS, acting on nicotinic receptors, modulating the hypoglossal and abdominal responses to hypercapnia. (AU)

FAPESP's process: 13/22526-4 - Cholinergic function of commissural nucleus of the solitary tract on cardiorespiratory responses to hypoxia, hypercapnia and pH decrease
Grantee:Werner Issao Furuya
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/17251-6 - Neural mechanisms generating the respiratory pattern and the respiratory-sympathetic coupling in conditions of hypoxia
Grantee:Daniel Breseghello Zoccal
Support type: Research Grants - Young Investigators Grants