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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Comparison of morphometry and ventricular function of healthy and smoking young people

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Ribeiro Batista, Ana Natalia [1] ; Garcia, Thais [1] ; Thome Franco, Estefania Aparecida [1] ; Azevedo, Paula Schmidt [1] ; Barbosa, Mauricio Fregonesi [1] ; Mamede Zornoff, Leonardo Antonio [1] ; Minicucci, Marcos Ferreira [1] ; Rupp de Paiva, Sergio Alberto [1] ; Zucchi, Jose William [1] ; de Godoy, Irma [1] ; Tanni, Suzana Erico [1]
Total Authors: 11
[1] Univ Estadual Paulista, UNESP, Univ Estadual Paulista, Botucatu Sch Med, Dept Clin Med, Botucatu, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: BMC CARDIOVASCULAR DISORDERS; v. 20, n. 1 FEB 6 2020.
Web of Science Citations: 0

Background Tobacco smoke is one of the most significant risk factors for cardiovascular diseases and damages in the myocardial tissue directly. Cardiac magnetic resonance (CMR) has been used and is a promising tool to evaluate morphometry and cardiac function in humans. The objective of this study was to evaluate associations of smoking with morphometry and cardiac function by CMR technique in young adult smokers. Methods Altogether, 49 volunteers (22 smokers and 27 non-smokers) were included in the study. The comparisons between groups were performed by multiple linear regression adjusting for body mass index and gender. Results In the morphometric and functional evaluation of the left ventricle, we observed statistical significant lower values of end-diastolic volume (EDV) (p = 0.02), ejection volume (EV) (p = 0.001) and indexed ejection volume (IEV) (p = 0.007) in smokers when compared to no-smoker group. Right ventricle showed statistical significant lower values of EDV (p = < 0.001), end-systolic volume (p = 0.01), EV (p = < 0.001), IEV (p = 0.001), indexed end-diastolic volume (p = 0.001) and major axis (p = 0.01) in smokers when compared to non-smokers group. Conclusions There is a strongly association of smoking in young adult and cardiac function decline, even adjusted by cofounders, which compromises the proper functioning of the heart. Evidence confirms that smoking can directly influence the cardiac function, even without atherosclerosis or other chronic comorbidities, associated with increased risk of cardiovascular diseases. (AU)

FAPESP's process: 15/06772-0 - Evaluation association of the smoking with acids wax deposition and cardiac hypertrophy
Grantee:Suzana Erico Tanni Minamoto
Support Opportunities: Regular Research Grants