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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Assessment of Executive Functions after Treatment of Childhood Acute Lymphoid Leukemia: a Systematic Review

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Godoy, Priscilla Brandi Gomes [1] ; Simionato, Natalia Maria [1] ; de Mello, Claudia Berlim [1] ; Suchecki, Deborah [1]
Total Authors: 4
[1] Univ Fed Sao Paulo, Dept Psicobiol, UNIFESP, Rua Napoleao de Barros 925, BR-04023062 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: NEUROPSYCHOLOGY REVIEW; v. 30, n. 3 JUL 2020.
Web of Science Citations: 0

Individuals treated for childhood acute lymphoblastic leukemia (ALL) have a high survival rate. This fact, however, may lead to neurocognitive impairments in survivors, as shown in some studies. The prefrontal cortex and executive functions seem to be particularly vulnerable due to the late maturation in the development process. Executive impairments have been associated with poorer quality of life in childhood cancer survivors. A systematic review was carried out with studies that assessed executive functions in childhood ALL survivors.\textbackslash{} Studies were collected from five electronic databases: MEDLINE (PubMed); PsycInfo; WebOfScience; LILACS and IBECS. Eighty-four studies were retrieved from the database search, of which 50 were read in full and 26 met the inclusion criteria. The studies were heterogeneous as to the instruments used to assess executive function, the skills assessed and the comparison methods. Despite some discrepancies, ALL survivors seem to exhibit poorer executive functioning than typical controls, but this result did not hold true when subjects were compared to normative mean. Changes in brain structure and dynamics resulting from the disease itself, the toxicity of the treatment and difficulties in coping with the stress during treatment may be related to executive impairments in ALL survivors. Discussion proposed standardized methods and measures for assessing executive functioning in children during and after ALL treatment. (AU)

FAPESP's process: 17/04483-7 - Depression, anxiety and executive functions in pediatric patients after acute leukemia treatment: a comparative study with siblings
Grantee:Priscilla Brandi Gomes Godoy
Support type: Scholarships in Brazil - Master