| Full text | |
| Author(s): |
de Paula-Silva, Marina
[1]
;
Broering, Milena Fronza
[1]
;
Scharf, Pablo
[1]
;
Oliveira da Rocha, Gustavo Henrique
[1]
;
Farsky, Sandra
[1]
;
Lino-dos-Santos-Franco, Adriana
[2]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Fac Pharmaceut Sci, Sao Paulo, SP - Brazil
[2] Univ Nove Julho UNINOVE, Postgrad Program Biophoton Appl Hlth Sci, Vergueiro St 239-245, BR-01504000 Sao Paulo, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY; v. 212, NOV 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Inflammatory bowel diseases are debilitating illnesses characterized by severe inflammation of the gastrointestinal tract. Treatments currently available are expensive and ineffective. We here investigated the role of red-light emitting diode (LED) on dextran sodium sulfate (DSS)-induced colitis. DSS was added to the drinking water of male mice at days 0, 2, 4 and withdrawn at day 6. LED irradiation was performed daily for 90s from day 6 to 9 on the right and left sides of the ventral surface and beside the external anal region. LED treatment decreased the amount of crypt dysplasia/edema, inflammatory infiltrates and ulcers, attenuated apoptosis and increased proliferation of crypt cells. Also, LED treatment induced expression of annexin Al in the damaged epithelium, preserved the organization of claudin-1 and skewed cytokine profiling towards a more anti-inflammatory status. Thus, LED treatment promotes structural protection and modulates the inflammatory response, constituting a potential non-invasive and low-cost combined therapy to help patients achieve disease remission. (AU) | |
| FAPESP's process: | 14/07328-4 - Identification of endogenous pathways for the control of inflammation |
| Grantee: | Sandra Helena Poliselli Farsky |
| Support Opportunities: | Research Projects - Thematic Grants |