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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Thermoprotective molecules to improve oocyte competence under elevated temperature

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Author(s):
Moura, Marcelo T. [1] ; Paula-Lopes, Fabiola F. [1]
Total Authors: 2
Affiliation:
[1] Fed Univ Sao Paulo UNIFESP, Dept Biol Sci, Diadema, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Theriogenology; v. 156, p. 262-271, OCT 15 2020.
Web of Science Citations: 0
Abstract

Heat stress is an environmental factor that challenges livestock by disturbing animal homeostasis. Despite the broad detrimental effects of heat stress on reproductive function, the germline and the early preimplantation embryo are particularly prone. There is extensive evidence that elevated temperature reduces oocyte developmental competence through a series of cellular and molecular damages. Further research revealed that the oocyte respond to stress by activating cellular mechanisms such as heat shock response, unfolded protein response and autophagy to improve survival under heat shock. Such knowledge paved the way for the identification of thermoprotective molecules that alleviate heat induced oocyte oxidative stress, organelle damage, and apoptosis. Therefore, this review depicts the deleterious effects of heat shock on oocyte developmental competence, heat-induced cellular and molecular changes, outlines pro-survival cellular mechanisms and explores thermoprotective molecules to improve oocyte competence. (c) 2020 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 17/20125-3 - Immediate and transgenerational epigenetic effects of heat stress on female gametes
Grantee:Fabíola Freitas de Paula Lopes
Support Opportunities: Research Program on Global Climate Change - Regular Grants