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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Degradable and colloidally stable zwitterionic-functionalized silica nanoparticles

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Schneid, Andressa C. [1, 2] ; Ribeiro, Iris R. S. [1, 2, 3] ; Galdino, Flavia E. [1, 2, 3] ; Bettini, Jefferson [1] ; Cardoso, Mateus B. [1, 2, 3]
Total Authors: 5
[1] Ctr Nacl Pesquisa Energia & Mat CNPEM, Lab Nacl Nanotecnol LNNano, BR-13083970 Campinas, SP - Brazil
[2] Ctr Nacl Pesquisa Energia & Mat CNPEM, Lab Nacl Luz Sincrotron LNLS, BR-13083970 Campinas, SP - Brazil
[3] Univ Estadual Campinas UNICAMP, Inst Quim IQ, Caixa Postal 6154, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Nanomedicine; JAN 2021.
Web of Science Citations: 0

Aim: This work is focused on obtaining degradable mesoporous silica nanoparticles (DMSNs) which are able to maintain their colloidal stability in complex biological media. Materials \& methods: DMSNs were synthesized using different ratios of disulfide organosilane (degradable structural moiety) and further functionalized with sulfobetaine silane (SBS) to enhance colloidal stability and improve biological compatibility. Results: There was a clear trade-off between nanoparticle degradability and colloidal stability, since full optimization of the degradation process generated unstable particles, while enhancing colloidal stability resulted in poor DMSNs degradation. It was also shown that acidic pH improved particle degradation which is commonly triggered by reduction stimulus. Conclusion: A chemical composition window was found where DMSNs presented satisfactory colloidal stability in biologically relevant medium, meaningful degradation profiles and high biocompatibility. {[}GRAPHICS] . (AU)

FAPESP's process: 17/21318-0 - Targeting of functionalized nanoparticles in microfluidics systems containing multiple organoids
Grantee:Iris Renata Sousa Ribeiro
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/09555-9 - Influence of protein corona on interaction and internalization of silica nanoparticles in human cells: from two-dimensional to tri-dimensional images
Grantee:Flávia Elisa Galdino
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/00763-8 - Synthesis of a Biodegradable Periodic Mesoporous Organosílica: A H. pylori Specific Drug Carrier
Grantee:Andressa da Cruz Schneid
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles
Grantee:Watson Loh
Support Opportunities: Research Projects - Thematic Grants